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indinavir (idv, crixivan  (Merck & Co)

 
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    Merck & Co indinavir (idv, crixivan
    Drugs currently used for HIV therapy.
    Indinavir (Idv, Crixivan, supplied by Merck & Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/indinavir (idv, crixivan/product/Merck & Co
    Average 90 stars, based on 1 article reviews
    indinavir (idv, crixivan - by Bioz Stars, 2026-02
    90/100 stars

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    1) Product Images from "New Therapies and Strategies to Curb HIV Infections with a Focus on Macrophages and Reservoirs"

    Article Title: New Therapies and Strategies to Curb HIV Infections with a Focus on Macrophages and Reservoirs

    Journal: Viruses

    doi: 10.3390/v16091484

    Drugs currently used for HIV therapy.
    Figure Legend Snippet: Drugs currently used for HIV therapy.

    Techniques Used:



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    Nelfinavir inhibits the proteolysis activity of recombinant Emu Ddi1 . Emu Ddi1 was expressed in an E. coli system. Based on the amino acid compositions, this molecular weight of the recombinant protein was predicted to be appropriately 45 KD in the monomer (left) and 90 KD in the dimer (right) (a). At an optimum pH of 7.2, the recombinant Emu Ddi1 was able to hydrolyze the retro-pepsin substrate with a Km = 1.28 (95% CI: 0.80 to 2.02) μM and a Kcat = 0.36 s –1 (b). The HIVPIs, including lopinavir (LPV), <t>indinavir</t> (IDV), darunavir (DRV), fosamprenavir (FAPV), ritonavir (RTV), tipranavir (TPV), atazanavir (ATV), amprenavir (APV), nelfinavir (NFV) and saquinavir (SQV) were tested (n = 3). The enzyme activity of this recombinant protein (at 0.5 μM) could be apparently blocked by nelfinavir (NFV) and saquinavir (SQV) (40 μM) (c). The half-maximal inhibitory concentration (IC 50 ) of nelfinavir on the recombinant Emu Ddi1 was 45.95 μM (d). The results shown are representative of two or more independent experiments. Data shown are represented as mean ± SD.
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    Image Search Results


    Drugs currently used for HIV therapy.

    Journal: Viruses

    Article Title: New Therapies and Strategies to Curb HIV Infections with a Focus on Macrophages and Reservoirs

    doi: 10.3390/v16091484

    Figure Lengend Snippet: Drugs currently used for HIV therapy.

    Article Snippet: Indinavir (IDV, Crixivan ® , developed by Merck & Co, Inc., Whitehouse Station, NJ, USA) was approved in 1996.

    Techniques:

    FDA-approved ART drugs and some of their reported mutations.

    Journal: Viruses

    Article Title: Current ARTs, Virologic Failure, and Implications for AIDS Management: A Systematic Review

    doi: 10.3390/v15081732

    Figure Lengend Snippet: FDA-approved ART drugs and some of their reported mutations.

    Article Snippet: , , Indinavir (IDV) , Crixivan ® , Merck & Co, Inc. New Jersey, USA. , , 32I, 46IL, 47V, 54VTALM, 76V, 82ATFS, 84V, 88S, 90M…etc..

    Techniques: Blocking Assay

    Antiretroviral drugs and their concentrations used

    Journal: Journal of Medical Virology

    Article Title: Cell‐to‐cell transmission of HIV‐1 from provirus‐activated cells to resting naïve and memory human primary CD4 T cells is highly efficient and requires CD4 and F‐actin but not chemokine receptors

    doi: 10.1002/jmv.28005

    Figure Lengend Snippet: Antiretroviral drugs and their concentrations used

    Article Snippet: Eight PIs were used including Amprenavir (APV; Sigma‐Aldrich), Atazanavir (ATV; APExBio), Darunavir (DRV; APExBio), Indinavir (IDV; Sigma‐Aldrich), Lopinavir (LPV; Selleckchem), Nelfinavir (NFV; Tocris, Avonmouth), Ritonavir (RTV; Sigma‐Aldrich), and Saquinavir (SQV; Tocris, Avonmouth).

    Techniques: Concentration Assay, Protease Inhibitor

    Nelfinavir inhibits the proteolysis activity of recombinant Emu Ddi1 . Emu Ddi1 was expressed in an E. coli system. Based on the amino acid compositions, this molecular weight of the recombinant protein was predicted to be appropriately 45 KD in the monomer (left) and 90 KD in the dimer (right) (a). At an optimum pH of 7.2, the recombinant Emu Ddi1 was able to hydrolyze the retro-pepsin substrate with a Km = 1.28 (95% CI: 0.80 to 2.02) μM and a Kcat = 0.36 s –1 (b). The HIVPIs, including lopinavir (LPV), indinavir (IDV), darunavir (DRV), fosamprenavir (FAPV), ritonavir (RTV), tipranavir (TPV), atazanavir (ATV), amprenavir (APV), nelfinavir (NFV) and saquinavir (SQV) were tested (n = 3). The enzyme activity of this recombinant protein (at 0.5 μM) could be apparently blocked by nelfinavir (NFV) and saquinavir (SQV) (40 μM) (c). The half-maximal inhibitory concentration (IC 50 ) of nelfinavir on the recombinant Emu Ddi1 was 45.95 μM (d). The results shown are representative of two or more independent experiments. Data shown are represented as mean ± SD.

    Journal: eBioMedicine

    Article Title: HIV protease inhibitor nelfinavir is a potent drug candidate against echinococcosis by targeting Ddi1-like protein

    doi: 10.1016/j.ebiom.2022.104177

    Figure Lengend Snippet: Nelfinavir inhibits the proteolysis activity of recombinant Emu Ddi1 . Emu Ddi1 was expressed in an E. coli system. Based on the amino acid compositions, this molecular weight of the recombinant protein was predicted to be appropriately 45 KD in the monomer (left) and 90 KD in the dimer (right) (a). At an optimum pH of 7.2, the recombinant Emu Ddi1 was able to hydrolyze the retro-pepsin substrate with a Km = 1.28 (95% CI: 0.80 to 2.02) μM and a Kcat = 0.36 s –1 (b). The HIVPIs, including lopinavir (LPV), indinavir (IDV), darunavir (DRV), fosamprenavir (FAPV), ritonavir (RTV), tipranavir (TPV), atazanavir (ATV), amprenavir (APV), nelfinavir (NFV) and saquinavir (SQV) were tested (n = 3). The enzyme activity of this recombinant protein (at 0.5 μM) could be apparently blocked by nelfinavir (NFV) and saquinavir (SQV) (40 μM) (c). The half-maximal inhibitory concentration (IC 50 ) of nelfinavir on the recombinant Emu Ddi1 was 45.95 μM (d). The results shown are representative of two or more independent experiments. Data shown are represented as mean ± SD.

    Article Snippet: HIV protease inhibitors (HIVPIs), including nelfinavir (NFV, CAS NO. 159989-64-7), lopinavir (LPV, CAS NO. 192725-17-0), indinavir (IDV, CAS NO.180686-37-8), darunavir (DRV, CAS NO. 206361-99-1), fosamprenavir (FAPV, CAS NO. 226700-79-4), ritonavir (RTV, CAS NO. 176655-55-3), tipranavir (TPV, CAS NO. 174484-41-4), atazanavir (ATV, CAS NO. 198904-31-3), saquinavir (SQV, CAS NO. 149845-06-7), and amprenavir (APV, CAS NO. 161814-49-9), were purchased from Macklin (Shanghai, China).

    Techniques: Activity Assay, Recombinant, Molecular Weight, Concentration Assay